Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics

@article{Xiu2009DecreasedSB,
  title={Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics},
  author={Mei Hong Xiu and Lim Ki Hui and Yu Feng Dang and Tian-de Hou and Chong Xi Zhang and You Lan Zheng and Da Chun Chen and Thomas R. Kosten and Xiang yang Zhang},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2009},
  volume={33},
  pages={1508-1512}
}
  • M. Xiu, L. Hui, X. Zhang
  • Published 13 November 2009
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
Decreased serum levels of brain-derived neurotrophic factor in schizophrenic patients with deficit syndrome
TLDR
It is suggested that decreased BDNF levels may play a role in the pathophysiology of schizophrenic patients with deficit syndrome, and additional studies using a larger patient sample size are needed.
Serum brain-derived neurotrophic factors in Taiwanese patients with drug-naïve first-episode schizophrenia: Effects of antipsychotics
  • Yu-Jie Chiou, Tiao-Lai Huang
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2017
TLDR
The peripheralBDNF levels in Taiwanese patients with drug-naïve first-episode schizophrenia, compared with healthy controls, did not elevate after antipsychotic treatment, and pre-treatment negative symptoms played a pivotal role in trajectories of serum BDNF levels.
Effects of antipsychotics on the serum BDNF levels in schizophrenia
Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia
TLDR
The findings suggest that BDNF may be involved in the pathophysiology of schizophrenia, and its associated cognitive impairment, especially immediate memory.
Association Between Depressive Symptoms and Serum Brain-Derived Neurotrophic Factor Levels in Patients With First-Episode and Drug-Naïve Schizophrenia
TLDR
Serum BDNF levels were shown to be higher in the serum of patients with FEDN schizophrenia with depressive symptoms than in those without, suggesting that low levels of serum BDNF may contribute to the positive symptoms of FEDn schizophrenia but not to depressive symptoms.
...
...

References

SHOWING 1-10 OF 34 REFERENCES
Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics
Reduced serum BDNF levels in schizophrenic patients on clozapine or typical antipsychotics.
Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics.
Reduced serum BDNF levels in patients with chronic schizophrenic disorder in relapse, who were treated with typical or atypical antipsychotics
  • E. Rizos, A. Papadopoulou, L. Lykouras
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2010
TLDR
The findings may indicate a differential effect of olanzapine on BDNF levels compared to haloperidol, risperidone, and amisulpride, and the possible differential effects of treatment with typical and atypical antipsychotics on serumBDNF levels in the same group of patients.
Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls
Associations between serum brain-derived neurotrophic factor levels and clinical phenotypes in schizophrenia patients.
Decreased levels of brain-derived neurotrophic factor in serum of chronic schizophrenic patients
...
...