Decreased serotonin transporter binding in unaffected relatives of manic depressive patients.

@article{Leboyer1999DecreasedST,
  title={Decreased serotonin transporter binding in unaffected relatives of manic depressive patients.},
  author={Marion Leboyer and Philippe Quintin and Philippe Manivet and Odile Varoquaux and Jean François Allilaire and Jean Marie Launay},
  journal={Biological psychiatry},
  year={1999},
  volume={46 12},
  pages={1703-6}
}
BACKGROUND There are numerous reports of decreased binding to platelet serotonin transporter (5-HTT) in depression, suggesting that it might be considered a trait marker of depression. To further investigate whether reduced 5-HTT function could be an endophenotype in manic depressive illness, we looked for abnormalities of platelet 5-HTT among subjects who are potential carriers of genetic vulnerability to manic depressive illness (MDI). METHODS Blood samples were obtained from 20 unaffected… CONTINUE READING