Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway.

@article{Carballo2001DecreasedSO,
  title={Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway.},
  author={Ester Carballo and Huiqing Cao and Wi S. Lai and Elizabeth A. Kennington and David G Campbell and Perry J. Blackshear},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={42580-7}
}
Treatment of macrophages with pyridinyl imidazole inhibitors of p38 protein kinases can inhibit lipopolysaccharide-stimulated tumor necrosis factor alpha secretion. However, bone marrow-derived macrophages from tristetraprolin (TTP)-deficient mice were less sensitive than normal macrophages to this effect of p38 inhibitors, despite evidence for normal p38 activation in response to lipopolysaccharide. TTP is known to cause decreased stability of tumor necrosis factor alpha and granulocyte… CONTINUE READING

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