Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation.

@article{Shanmugam2011DecreasedSP,
  title={Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation.},
  author={Mayilvahanan Shanmugam and Cristina E. Molina and Shumin Gao and Renaud Severac-Bastide and Rodolphe Fischmeister and Gopal Jegadeesh Babu},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={410 1},
  pages={97-101}
}
Sarcolipin (SLN), a key regulator of cardiac sarco(endo)plasmic reticulum (SR) Ca(2+) ATPase, is predominantly expressed in atria and mediates β-adrenergic responses. Studies have shown that SLN mRNA expression is decreased in human chronic atrial fibrillation (AF) and in aortic banded mouse atria; however, SLN protein expression in human atrial pathology and its role in atrial SR Ca(2+) uptake are not yet elucidated. In the present study, we determined the expression of major SR Ca(2… CONTINUE READING