Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux.

@article{Remaley1997DecreasedRC,
  title={Decreased reverse cholesterol transport from Tangier disease fibroblasts. Acceptor specificity and effect of brefeldin on lipid efflux.},
  author={Alan T Remaley and Ulrike K. Schumacher and John A. Stonik and B D Farsi and Hassan Nazih and Hollis B Brewer},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1997},
  volume={17 9},
  pages={1813-21}
}
Tangier disease is characterized by HDL hypercatabolism and increased deposition of cholesterol in tissues. Tangier disease skin fibroblasts have decreased apoA-I-mediated cholesterol and phospholipid efflux, which may lead to the excess accumulation of cellular cholesterol. The mechanism of apolipoprotein-mediated cholesterol efflux and the apolipoprotein acceptor specificity for cholesterol efflux from normal and Tangier disease fibroblasts was investigated. Normal cells readily effluxed… CONTINUE READING
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