Decreased responsiveness to progesterone of spermatozoa in oligozoospermic patients.

@article{Falsetti1993DecreasedRT,
  title={Decreased responsiveness to progesterone of spermatozoa in oligozoospermic patients.},
  author={C Falsetti and Elisabetta Baldi and C Krausz and R Casano and Paola Failli and Gianni Forti},
  journal={Journal of andrology},
  year={1993},
  volume={14 1},
  pages={17-22}
}
Spermatozoa from oligozoospermic subjects are characterized by a reduced in vitro ability to penetrate hamster oocytes and by a decreased responsiveness to physiological stimuli that trigger the acrosome reaction. One of the first steps in the induction of the acrosome reaction is an increase of intracellular free calcium concentrations ([Ca2+]i). It has been recently shown that progesterone (P) is able to increase [Ca2+]i in capacitated human sperm at concentrations similar to those found in… CONTINUE READING