Decreased reproductive effects from snakeweed (Gutierrezia microcephala) in Sprague-Dawley rats with increased dietary snakeweed consumption.

@article{Staley1996DecreasedRE,
  title={Decreased reproductive effects from snakeweed (Gutierrezia microcephala) in Sprague-Dawley rats with increased dietary snakeweed consumption.},
  author={E C Staley and G. Stanley Smith and James Adam Greenberg},
  journal={Veterinary and human toxicology},
  year={1996},
  volume={38 4},
  pages={259-64}
}
Sprague-Dawley rats have been used to study the pathogenesis and toxicokinetics of snakeweed (Gutierrezia microcephala and G sarothrae) toxicosis. Diets containing as little as 10% snakeweed (SW) will induce early embryonic toxicosis and abortion in Sprague-Dawley rats. The sc administration of safflower oil to inseminated female rats will provide protection/tolerance against SW embryotoxins. Two studies evaluated this embryotoxin protection. In the first study, an increase in daily consumption… CONTINUE READING