Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters.

@article{Perchellet1986DecreasedRO,
  title={Decreased ratio of reduced/oxidized glutathione in mouse epidermal cells treated with tumor promoters.},
  author={Jean Pierre Perchellet and Elisabeth M. Perchellet and D K Orten and Bruce A. Schneider},
  journal={Carcinogenesis},
  year={1986},
  volume={7 3},
  pages={503-6}
}
Cellular pro-oxidant states appear to play role in the promotion phase, presumably because tumor promoter-treated cells overproduce activated forms of oxygen and/or deficient in their ability to destroy them. Since one of the earliest responses to the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) may be the generation of reactive oxygen species, we have determined the effects of this compound on the natural glutathione-dependent antioxidant protective system of the epidermal… CONTINUE READING
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