Decreased raphe unit activity in a rat model of endogenous depression.

@article{Yavari1993DecreasedRU,
  title={Decreased raphe unit activity in a rat model of endogenous depression.},
  author={P Yavari and Gerald W. Vogel and Darryl B Neill},
  journal={Brain research},
  year={1993},
  volume={611 1},
  pages={31-6}
}
One theory about the pathogenesis of endogenous depression is that decreased serotonergic (5-HT) neurotransmission is involved in producing the disorder. A key component of brain 5-HT neurotransmission is the discharge rate of 5-HT neurons in the dorsal raphe nucleus (DRN), a major aggregation of 5-HT neurons. We tested the hypothesis that the discharge rate of 5-HT neurons in the DRN was decreased in a new animal (rat) model of human endogenous depression. In this model, rats are treated… CONTINUE READING

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