Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

@article{Grune2004DecreasedPC,
  title={Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.},
  author={T. Grune and Tobias Jung and Katrin Merker and Kelvin J A Davies},
  journal={The international journal of biochemistry & cell biology},
  year={2004},
  volume={36 12},
  pages={2519-30}
}
Protein aggregation seems to be a common feature of several neurodegenerative diseases and to some extent of physiological aging. It is not always clear why protein aggregation takes place, but a disturbance in the homeostasis between protein synthesis and protein degradation seems to be important. The result is the accumulation of modified proteins, which tend to form high molecular weight aggregates. Such aggregates are also called inclusion bodies, plaques, lipofuscin, ceroid, or 'aggresomes… CONTINUE READING

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