Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease.

@article{Cheon2001DecreasedPL,
  title={Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease.},
  author={Min Suk Cheon and Michael Fountoulakis and Nigel J. Cairns and Mara Dierssen and Kurt R. Herkner and Gert Lubec},
  journal={Journal of neural transmission. Supplementum},
  year={2001},
  volume={61},
  pages={281-8}
}
Stathmin, distributed in neurons with high abundance, acts as an intracellular relay, integrating various transduction pathways triggered by extracellular signals and it is involved in physiological regulation of microtubule destabilization. Stathmin has been also shown to be a critical molecule in pathology of neurodegeneration such as Alzheimer's disease (AD), particularly, in neurofibrillary tangle (NFT) formation. Here we evaluated protein levels of stathmin in adult brain from patients… CONTINUE READING

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