Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts.

@article{ElArmouche2004DecreasedPA,
  title={Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts.},
  author={Ali El-Armouche and Torsten Pamminger and Diana Ditz and Oliver Zolk and Thomas Eschenhagen},
  journal={Cardiovascular research},
  year={2004},
  volume={61 1},
  pages={
          87-93
        }
}
OBJECTIVE The protein phosphatase inhibitor-1 (I-1) is a highly specific and potent inhibitor of type 1 phosphatases (PP1) that is active only in its protein kinase A (PKA)-phosphorylated form. I-1 ablation decreases, I-1 overexpression sensitizes beta-adrenergic signaling in the heart. It is controversial whether I-1 expression is altered in human heart failure (HF), likely because its detection in heart is difficult due to its low abundance. METHODS AND RESULTS I-1 was >500-fold enriched… CONTINUE READING
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Evidence for protein phosphatase inhibitor - 1 playing a role in h - adrenergic desensitazion observed in heart failure

  • A El-Armouche, E Jäckel, T Pamminger, T Eschenhagen
  • Naunyn - Schmiedeberg ’ s Arch Pharmacol
  • 2002

Evidence for protein phosphatase inhibitor-1 playing a role in h-adrenergic desensitazion observed in heart failure. Naunyn-Schmiedeberg’s Arch Pharmacol 2002;365:R88

  • A El-Armouche, E Jäckel, T Pamminger, T. Eschenhagen
  • 2002
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