Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats.

Abstract

Chronic hypothyroidism is associated with an increased risk for cardiovascular disease attributed, in part, to increased serum cholesterol and atherosclerosis. Decreased hepatic activity of cholesterol 7a-hydroxylase (CYP7A1) is thought to contribute to hypercholesterolemia in hypothyroidism. The endoplasmic reticulum (ER) has been shown to be a central… (More)
DOI: 10.1111/j.1440-1827.2009.02435.x

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@article{Zhou2009DecreasedPA, title={Decreased protein and gene expression of hepatic cholesterol 7a-hydroxylase associated with dilated endoplasmic reticulum in chronic hypothyroid rats.}, author={Xinli Zhou and Y. Y. Han and Jia Liu and Ling Gao and Jiajun Zhao}, journal={Pathology international}, year={2009}, volume={59 10}, pages={729-34} }