Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemophilus influenzae type b.

@article{Schreiber1985DecreasedPE,
  title={Decreased protective efficacy of reduced and alkylated human immune serum globulin in experimental infection with Haemophilus influenzae type b.},
  author={J. Schreiber and V. Barrus and G. Siber},
  journal={Infection and immunity},
  year={1985},
  volume={47 1},
  pages={
          142-8
        }
}
  • J. Schreiber, V. Barrus, G. Siber
  • Published 1985
  • Biology, Medicine
  • Infection and immunity
  • Conventionally prepared immune serum globulin frequently produces severe side effects when administered intravenously. A modified preparation in which 4 to 5 interchain disulfide bonds have been reduced and alkylated has been made for intravenous use. However, reduction and alkylation may affect Fc-mediated functions of immunoglobulin G, particularly its ability to fix complement by the classical pathway. To determine whether reduction and alkylation alters the protective activity of immune… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Efficacy of human hyperimmune globulin in prevention of Haemophilus influenzae type b disease in infant rats.
    • 35
    • PDF
    Complement interaction with immune serum globulin and immune globulin intravenous.
    • D. Bing
    • Medicine
    • The American journal of medicine
    • 1984
    • 23
    Quantitative Measurement of “Natural” and Immunization-induced Haemophilus influenzas type b Capsular Polysaccharide Antibodies
    • 261
    • Highly Influential
    • PDF
    Experimental Haemophilus influenzae type b meningitis: immunological investigation of the infant rat model.
    • 32
    • PDF
    The role of specific antibody in alternative complement pathway- mediated opsonophagocytosis of type III, group B Streptococcus
    • 155
    • PDF
    Bactericidal and opsonic properties of C4-deficient guinea pig serum.
    • 66
    The critical role of complement in experimental pneumococcal sepsis.
    • 82