Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence.

@article{Ponnappan1999DecreasedPD,
  title={Decreased proteasome-mediated degradation in T cells from the elderly: A role in immune senescence.},
  author={Usha Ponnappan and Mei-zuo Zhong and G U Trebilcock},
  journal={Cellular immunology},
  year={1999},
  volume={192 2},
  pages={167-74}
}
Induction of NFkappaB is a highly regulated process requiring phosphorylation, ubiquitination, and proteasome-mediated degradation of the cytosolic inhibitor IkappaBalpha. Analyses of the regulation of IkappaBalpha in TNF-alpha-treated T lymphocytes from young and elderly donors revealed severely compromised degradation of IkappaBalpha in T cells from the elderly. Examination of activation-induced phosphorylation and ubiquitination of IkappaBalpha did not demonstrate any significant age-related… CONTINUE READING

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