Decreased production ofpara-hydroxypenicillin V in penicillin V fermentations

@article{Chang2005DecreasedPO,
  title={Decreased production ofpara-hydroxypenicillin V in penicillin V fermentations},
  author={L. T. Chang and E. McGrory and R. Elander and D. J. Hook},
  journal={Journal of Industrial Microbiology},
  year={2005},
  volume={7},
  pages={175-179}
}
  • L. T. Chang, E. McGrory, +1 author D. J. Hook
  • Published 2005
  • Chemistry, Medicine
  • Journal of Industrial Microbiology
  • SummaryPenicillin V (phenoxymethyl penicillin) is produced by industrial strains ofPenicillium chrysogenum in the presence of phenoxyacetic acid (POAc), a side-chain precursor for the penicillin V molecule. The wild-type strain ofP. chrysogenum produces an undesirable penicillin byproduct,para-hydroxypenicillin V (p-OH penicillin V), in addition to penicillin V, viapara-hydroxylation of POAc and subsequent incorporation of thep-OH phenoxyacetic acid into the penicillin molecule. Most of thep-OH… CONTINUE READING
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