Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus.

@article{Horwitz1998DecreasedPO,
  title={Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus.},
  author={David Allen Horwitz and J. Dixon Gray and S C Behrendsen and Marek Kubin and M Rengaraju and Kazuo Ohtsuka and Giorgio Trinchieri},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 5},
  pages={838-44}
}
OBJECTIVE To determine the profile of Th1-type and Th2-type cytokines produced by mononuclear cells from patients with recent-onset systemic lupus erythematosus (SLE), prior to the initiation of treatment with corticosteroids. METHODS Using sensitive radioimmunoassays, interleukin-4 (IL-4), IL-10, IL-12 p40, tumor necrosis factor alpha (TNF alpha), interferon-gamma (IFN gamma), and granulocyte-macrophage colony-stimulating factor (GM-CSF) released into the culture supernatants of various… CONTINUE READING
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