Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.

@article{AlcocerVarela1982DecreasedPO,
  title={Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus.},
  author={Jorge Alcocer-Varela and Donato Alarc{\'o}n-Segovia},
  journal={The Journal of clinical investigation},
  year={1982},
  volume={69 6},
  pages={1388-92}
}
We studied the production of and response to interleukin-2 (IL-2) by peripheral blood T lymphocytes from 19 systemic lupus erythematosus (SLE) patients who received no treatment at the time they were studied. Eight had active disease and the rest were in remission. Results were compared with those obtained in 12 healthy subjects of similar age. T cells from SLE patients, whether activated with phytohemagglutinin or in autologous mixed lymphocyte reactions, were found to yield little IL-2, to… CONTINUE READING