Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus.

@article{Ohtsuka1998DecreasedPO,
  title={Decreased production of TGF-beta by lymphocytes from patients with systemic lupus erythematosus.},
  author={Kichirou Ohtsuka and J. Dixon Gray and Mary M. Stimmler and Bricia Toro and David A. Horwitz},
  journal={Journal of immunology},
  year={1998},
  volume={160 5},
  pages={
          2539-45
        }
}
TGF-beta has marked inhibitory effects on the immune system but also serves as a costimulatory factor in the development of T cells with down-regulatory activities. This cytokine is secreted as a latent complex and converted extracellularly to its active form. We have recently learned that anti-CD2 is a potent inducer of lymphocyte-derived TGF-beta and that NK cells are the predominant source. The objective of this study was to compare levels of constitutive, anti-CD2-induced and cytokine… CONTINUE READING

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