Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET

@article{Okubo1997DecreasedPD,
  title={Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET},
  author={Yoshiro Okubo and Tetsuya Suhara and Kazutoshi Suzuki and Kaoru Kobayashi and Osamu Inoue and O. Terasaki and Yasuhiro Someya and Takeshi Sassa and Yasuhiko Sudo and Eisuke Matsushima and Masaomi Iyo and Yukio Tateno and Michio Toru},
  journal={Nature},
  year={1997},
  volume={385},
  pages={634-636}
}
Schizophrenia is believed to involve altered activation of dopamine receptors, and support for this hypothesis conies from the antipsychotic effect of antagonists of the dopamine D2 receptor (D2R)1. D2R is expressed most highly in the striatum, but most of the recent positron emission tomography (PET) studies have failed to show any change in D2R densities in the striatum of schizophrenics2–5, raising the possibility that other receptors may also be involved. In particular, the dopamine D1… CONTINUE READING
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