Decreased polysomal HSP-70 may slow polypeptide elongation during skeletal muscle atrophy.

@article{Ku1995DecreasedPH,
  title={Decreased polysomal HSP-70 may slow polypeptide elongation during skeletal muscle atrophy.},
  author={Z Ku and Jun Yang and V. B. Menon and Donald B. Thomason},
  journal={The American journal of physiology},
  year={1995},
  volume={268 6 Pt 1},
  pages={
          C1369-74
        }
}
Slowed elongation rate is the apparent cause of the rapid decrease in rat soleus muscle protein synthesis rate during non-weight bearing. We found that elongation factor 2 was not phosphorylated and thus could not explain the slowed elongation rate. However, we observed a 44 +/- 19 and 28 +/- 14% decrease in the chaperone protein 70-kDa heat-shock cognate/heat shock protein (HSC/HSP-70) associated with the polysomes after 12 and 18 h of non-weight bearing, respectively. Size-fractionated… CONTINUE READING

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