Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients.

@article{Bajaj2004DecreasedPA,
  title={Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients.},
  author={Mandeep Bajaj and Swangjit Suraamornkul and Paul K Piper and L. J. Hardies and Leonard Glass and Eugenio Cersosimo and Thongchai Pratipanawatr and Yoshinori Miyazaki and Ralph A DeFronzo},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2004},
  volume={89 1},
  pages={200-6}
}
The effect of pioglitazone (PIO) on plasma adiponectin concentration, endogenous glucose production (EGP), and hepatic fat content (HFC) was studied in 11 type 2 diabetic patients (age, 52 +/- 2 yr; body mass index, 29.6 +/- 1.1 kg/m(2); HbA(1c), 7.8 +/- 0.4%). HFC (magnetic resonance spectroscopy) and basal plasma adiponectin concentration were quantitated before and after PIO (45 mg/d) for 16 wk. Subjects received a 3-h euglycemic insulin (100 mU/m(2).min) clamp combined with 3-[(3)H] glucose… CONTINUE READING

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