Decreased physical performance of congenic mice with mismatch between the nuclear and the mitochondrial genome.

@article{Nagao1998DecreasedPP,
  title={Decreased physical performance of congenic mice with mismatch between the nuclear and the mitochondrial genome.},
  author={Yasumitsu Nagao and Yoshikazu Totsuka and Yoriko Atomi and Hideki Kaneda and Kirsten Fischer Lindahl and Hiroshi Imai and Hiromichi Yonekawa},
  journal={Genes & genetic systems},
  year={1998},
  volume={73 1},
  pages={21-7}
}
Maternal transmission of mitochondrial DNA (mtDNA) allows us to generate mtDNA congenic strain by repeating backcrosses of female mice to male mice of an inbred strain, which carries different mtDNA haplotype from that of the female progenitor. Since genetic backgrounds of inbred strains commonly used (e.g., C57BL/6J [B6] and BALB/c) are mainly derived from… CONTINUE READING