Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.

@article{Allen2009DecreasedPF,
  title={Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.},
  author={Kyle D. Allen and Timothy M Griffin and Ramona Marie Rodriguiz and William C. Wetsel and Virginia B. Kraus and J L A - NIH Huebner and Lawrence M. Boyd and Lori A. Setton},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 9},
  pages={2684-93}
}
OBJECTIVE In mice with Col9a1 gene inactivation (Col9a1(-/-)), osteoarthritis (OA) and intervertebral disc degeneration develop prematurely. The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies. METHODS Col9a1(-/-) and wild-type mice were investigated for reflexes, functional impairment (beam walking, pole climbing, wire hang, grip strength), sensorimotor skills (rotarod), mechanical sensitivity (von… CONTINUE READING

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