Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD

Abstract

The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. The aim of this study was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway… (More)
DOI: 10.1152/ajplung.00382.2016

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