Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.

@article{Lonskaya2013DecreasedPS,
  title={Decreased parkin solubility is associated with impairment of autophagy in the nigrostriatum of sporadic Parkinson's disease.},
  author={Irina Lonskaya and Michaeline L. Hebron and Norah K. Algarzae and Nicole M. Desforges and Charbel Moussa},
  journal={Neuroscience},
  year={2013},
  volume={232},
  pages={90-105}
}
Parkinson's disease (PD) is a motor disorder that involves death of dopaminergic neurons in the substantia nigra pars compacta. Parkin is an autosomal recessive gene that is mutated in early onset PD. We investigated the role of parkin and autophagic clearance in postmortem nigrostriatal tissues from 22 non-familial sporadic PD patients and 15 control samples. Parkin was insoluble with altered cytosolic expression in the nigrostriatum of sporadic PD. Parkin insolubility was associated with lack… CONTINUE READING
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