Decreased pallidal GABA following reverse microdialysis with clozapine, but not haloperidol.

@article{See2001DecreasedPG,
  title={Decreased pallidal GABA following reverse microdialysis with clozapine, but not haloperidol.},
  author={Ronald Eugene See and William J Berglind},
  journal={Neuroreport},
  year={2001},
  volume={12 17},
  pages={3655-8}
}
Changes in striatopallidal GABA are believed to play a significant role in the motor side effects produced by antipsychotic drugs (APDs). In the current study, we measured extracellular GABA in the globus pallidus (GP) of rats. GABA release was partially impulse- and Ca2+-dependent, as evidenced by decreased efflux following tetrodotoxin (TTX) or removal of Ca2+. In addition, GABA release was significantly increased by high K+ (100 mM KCl) stimulation. Reverse dialysis of the atypical APD… CONTINUE READING

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