Decreased pain tolerance and mood in recreational users of MDMA

@article{ORegan2003DecreasedPT,
  title={Decreased pain tolerance and mood in recreational users of MDMA},
  author={Margaret Claire O’Regan and Angela Clow},
  journal={Psychopharmacology},
  year={2003},
  volume={173},
  pages={446-451}
}
3,4-Methylenedioxymethamphetamine (MDMA) is known to affect brain serotonin (5-HT) neurons in experimental animals. However, its effects on humans are more difficult to infer. Serotonin is implicated in the body’s ability to modulate the effects of pain and to regulate mood. The aim of this research is to test nociceptive responses and mood in MDMA users as an index of central 5-HT function. Measurements of pain tolerance were obtained using the cold-pressor test for 15 polydrug users who… CONTINUE READING

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