Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice.

@article{Kovacs2005DecreasedOS,
  title={Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice.},
  author={Krisztina M. Kovacs and Istvan Szakall and Danielle O'Brien and R. C. Wang and K. Yaragudri Vinod and Mitsuo Saito and Fr{\'e}d{\'e}ric Simonin and Brigitte Lina Kieffer and Csaba Vad{\'a}sz},
  journal={Alcoholism, clinical and experimental research},
  year={2005},
  volume={29 5},
  pages={730-8}
}
BACKGROUND Although a large body of evidence suggests a role for the opioid system in alcoholism, the precise role of mu-, delta-, kappa-, and ORL1-opioid receptors and the physiological significance of their natural genetic variation have not been identified. The method of targeted gene disruption by homologous recombination has been used to knock out (KO) genes coding for opioid receptors, and study their effects on alcohol self-administration. Here we examined the effects of targeted… CONTINUE READING

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