Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy.

Abstract

AIM A comparison of retinal thickness (RT) measurements with optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (DM) and no or minimal diabetic retinopathy (DR) versus healthy controls. METHODS Fifty-three patients with type 1 DM with no or minimal DR underwent full ophthalmic examination, fundus photography and OCT. Mean RT measured by OCT was calculated for the central fovea, the fovea, the pericentral and the peripheral area of the macula, and compared to healthy controls. RESULTS Mean RT in the pericentral area was lower in patients with minimal DR (267 microm +/- 20 microm; n = 23) compared to healthy controls (281 microm +/-13 microm; p = 0.005; n = 28). Mean pericentral RT in patients without DR (276 microm +/-14 microm; n = 30) was less than pericentral RT in healthy controls, but higher than in patients with minimal DR, without being statistically significant. None of the other regions showed a significant change. CONCLUSION In this study a significantly decreased pericentral RT was measured in patients with minimal DR compared to healthy controls. This could be explained by a loss of intraretinal neural tissue in the earliest stage of DR.

0501002008200920102011201220132014201520162017
Citations per Year

222 Citations

Semantic Scholar estimates that this publication has 222 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Biallosterski2007DecreasedOC, title={Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathy.}, author={Carine Biallosterski and Mirjam E J van Velthoven and Robert Michels and Reinier Otto Schlingemann and J. Hans DeVries and Frank D. Verbraak}, journal={The British journal of ophthalmology}, year={2007}, volume={91 9}, pages={1135-8} }