Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.

@article{Ogawa1998DecreasedNO,
  title={Decreased nitric oxide-mediated natural killer cell activation in chronic fatigue syndrome.},
  author={Michio Ogawa and Tetsuo Nishiura and Masafumi Yoshimura and Yoko Horikawa and Hiroki Yoshida and Yu Okajima and Itaru Matsumura and Jun Ishikawa and Hirohisa Nakao and Yoshiaki Tomiyama and Yoshio Kanayama and Yuzuru Kanakura and Yuji Matsuzawa},
  journal={European journal of clinical investigation},
  year={1998},
  volume={28 11},
  pages={937-43}
}
BACKGROUND L-Arginine (L-Arg), one of the essential amino acids, has been reported to have an immunomodulatory effect. The precise mechanism of the L-Arg-induced natural killer (NK) cell activation remains unresolved,and the effect of L-Arg on NK cells in chronic fatigue syndrome (CFS) patients has not been estimated. METHODS NK cell function was evaluated in 20 subjects with CFS and compared with that in 21 healthy individuals. RESULTS In healthy control subjects, NK activity was… CONTINUE READING