Decreased nitric oxide markers and morphological changes in the brain of arsenic-exposed rats.

@article{Ros2009DecreasedNO,
  title={Decreased nitric oxide markers and morphological changes in the brain of arsenic-exposed rats.},
  author={Rosalva R{\'i}os and Sergio Zaraz{\'u}a and Martha E Santoyo and Julio Sep{\'u}lveda-Saavedra and Viktor Javier Romero-D{\'i}az and V. I. Jim{\'e}nez and Francisca P{\'e}rez-Severiano and Guadalupe C Vidal-Cant{\'u} and J. M. Delgado and Mar{\'i}a E. Jim{\'e}nez-Capdeville},
  journal={Toxicology},
  year={2009},
  volume={261 1-2},
  pages={68-75}
}
Epidemiological studies demonstrate an association between chronic consumption of arsenic contaminated water and cognitive deficits, especially when the exposure takes place during childhood. This study documents structural changes and nitrergic deficits in the striatum of adult female Wistar rats exposed to arsenic in drinking water (3 ppm, approximately 0.4 mg/kg per day) from gestation, throughout lactation and development until the age of 4 months. Kainic acid injected animals (10mg/kg, i.p… CONTINUE READING
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