Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients.

@article{Camilletti2001DecreasedNO,
  title={Decreased nitric oxide levels and increased calcium content in platelets of hypertensive patients.},
  author={Andrea Camilletti and N. Moretti and Gilberta Giacchetti and Emanuela Faloia and Daniela Martarelli and Franco Mantero and Laura Mazzanti},
  journal={American journal of hypertension},
  year={2001},
  volume={14 4 Pt 1},
  pages={
          382-6
        }
}
Decreased levels of nitric oxide (NO) may contribute to impaired endothelium-dependent vasodilatation in essential hypertension. Moreover, in hypertension, major platelets aggregation and endothelial adhesion, and increased atherogenetic risks are also present. Nitric oxide produced by platelet NO synthase, which is similar to endothelial NO synthase, inhibits platelets aggregation by increasing cytoplasmic cyclic GMP levels and contributes in a major way to the antithrombogenic properties of… CONTINUE READING

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