Decreased neutral endopeptidases: Possible role in inflammatory diseases of airways

  title={Decreased neutral endopeptidases: Possible role in inflammatory diseases of airways},
  author={Jay A. Nadel},
Neutral endopeptidase exists on the membranes of many cells in the airways. By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides. The selectivity of the enzyme is due, at least in part, to its close association with tachykinin receptors. By cleaving and inactivating the tachykinins, it limits the concentration of tachykinin that reaches the receptor. Decreased NEP activity produced by selective enzyme inhibitors, air pollutants… CONTINUE READING

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tnhibitors of neutral endopeptidase potentiate electrically and capsaicin-induced noncholinergic contraction in guinea pig bronchi

  • TD Djokic, JA NadeI, DJ Dusser, K Sekizawa, PD Graf, DB Borson
  • J Pharmacol Exp Ther
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