Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury.

@article{Chen2004DecreasedNF,
  title={Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury.},
  author={Zhiping Chen and John F. Keaney and Eberhard Schulz and Bruce S Levison and Lian Yu Shan and Masashi Sakuma and Xiaobin Zhang and Can Shi and Stanley L. Hazen and Daniel I. Simon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 35},
  pages={13014-9}
}
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are produced, in part, from NADPH oxidase in response to host invasion and tissue injury. Defects in NADPH oxidase impair host defense; however, the role of ROS and RNS in the response to tissue injury is not known. We addressed this issue by subjecting leukocyte oxidase (Nox2)-deficient (Nox2-/-) mice to arterial injury. Femoral artery injury was associated with increased Nox2 expression, ROS/RNS production, and oxidative… CONTINUE READING

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