Decreased morphine intake by opiate addicted rats administered zimelidine, a 5-HT uptake inhibitor

@article{Rnnbck2004DecreasedMI,
  title={Decreased morphine intake by opiate addicted rats administered zimelidine, a 5-HT uptake inhibitor},
  author={L. R{\"o}nnb{\"a}ck and J. Zeuchner and L. Rosengren and A. Wronski and S. Ögren},
  journal={Psychopharmacology},
  year={2004},
  volume={82},
  pages={30-35}
}
Zimelidine, a specific 5-HT uptake inhibitor, reduced peroral morphine consumption by morphine-addicted adult male and female Sprague-Dawley rats and old male rats in choice tests. The effect was dose dependent in male rats. Thus, the availability of central 5-HT appears to be important for the regulation of morphine preference in rat. The results are discussed in relation to recent literature where ethanol preference has been found to be attenuated by zimelidine. The results may provide… Expand
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