Decreased microglial activation in MS patients treated with glatiramer acetate

  title={Decreased microglial activation in MS patients treated with glatiramer acetate},
  author={John N. Ratchford and Christopher J. Endres and Dima A. Hammoud and Martin G. Pomper and Navid Shiee and John B McGready and Dzung L. Pham and Peter A. Calabresi},
  journal={Journal of Neurology},
Activated microglia are thought to be an important contributor to tissue damage in multiple sclerosis (MS). The level of microglial activation can be measured non-invasively using [11C]-R-PK11195, a radiopharmaceutical for positron emission tomography (PET). Prior studies have identified abnormalities in the level of [11C]-R-PK11195 uptake in patients with MS, but treatment effects have not been evaluated. Nine previously untreated relapsing-remitting MS patients underwent PET and magnetic… CONTINUE READING
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Cortical microglial activation is associated with disability in secondary progressive multiple sclerosis: an in vivo imaging study

  • M Politis, P Giannetti, +7 authors P Piccini
  • Neurology 74:A290
  • 2010
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