Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

@article{Liu1999DecreasedML,
  title={Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.},
  author={Rui Yang Liu and J N Zhou and Joop J. Van Heerikhuize and Michel A. Hofman and Dick F. Swaab},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 1},
  pages={323-7}
}
Sleep disruption, nightly restlessness, sundowning, and other circadian disturbances are frequently seen in Alzheimer's disease (AD) patients. Changes in the suprachiasmatic nucleus and pineal gland are thought to be the biological basis for these behavioral disturbances. Melatonin is the main endocrine message for circadian rhythmicity from the pineal. To determine whether melatonin production was affected in AD, melatonin levels were determined in the cerebrospinal fluid (CSF) of 85 patients… CONTINUE READING