Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

@inproceedings{Miwa2016DecreasedMS,
  title={Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria},
  author={Satomi Miwa and Rafal Czapiewski and Tengfei Wan and Amy Bell and Kirsten N. Hill and Thomas von Zglinicki and Gabriele Saretzki},
  booktitle={Aging},
  year={2016}
}
Telomerase in its canonical function maintains telomeres in dividing cells. In addition, the telomerase protein TERT has non-telomeric functions such as shuttling to mitochondria resulting in a decreased oxidative stress, DNA damage and apoptosis. TERT protein persists in adult neurons and can co-localise to mitochondria under various stress conditions. We show here that TERT expression decreased in mouse brain during aging while release of reactive oxygen species (ROS) from the mitochondrial… CONTINUE READING

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