Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus.

@article{Krishnadasan2002DecreasedLI,
  title={Decreased lung ischemia-reperfusion injury in rats after preoperative administration of cyclosporine and tacrolimus.},
  author={Baiya Krishnadasan and B Jagannatham Naidu and Matthew Randall Rosengart and Angie L Farr and Alison Patrucco Barnes and Edward Donald Verrier and Michael S. Mulligan},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2002},
  volume={123 4},
  pages={756-67}
}
OBJECTIVES Calcineurin inhibitors reduce experimental reperfusion injury in the liver, brain, heart, kidney, and small bowel. These studies were undertaken to determine whether these agents are similarly protective against lung ischemia-reperfusion injury. METHODS Left lungs of male rats were rendered ischemic for 90 minutes and reperfused for as long as 4 hours. Treated animals received cyclosporine A (INN: ciclosporin; 1 or 5 mg/kg) or tacrolimus (0.2 mg/kg) 6 hours before ischemia, at… CONTINUE READING

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