Decreased limbic and increased fronto-parietal connectivity in unmedicated patients with obsessive-compulsive disorder.

@article{Gttlich2014DecreasedLA,
  title={Decreased limbic and increased fronto-parietal connectivity in unmedicated patients with obsessive-compulsive disorder.},
  author={Martin G{\"o}ttlich and Ulrike M. Kr{\"a}mer and Andreas Kordon and Fritz Hohagen and Bartosz Zurowski},
  journal={Human brain mapping},
  year={2014},
  volume={35 11},
  pages={5617-32}
}
Obsessive-compulsive disorder (OCD) is characterized by recurrent intrusive thoughts and ritualized, repetitive behaviors, or mental acts. Convergent experimental evidence from neuroimaging and neuropsychological studies supports an orbitofronto-striato-thalamo-cortical dysfunction in OCD. Moreover, an over excitability of the amygdala and over monitoring of thoughts and actions involving the anterior cingulate, frontal and parietal cortex has been proposed as aspects of pathophysiology in OCD… CONTINUE READING
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