Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity.

@article{Matsushita2016DecreasedLO,
  title={Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity.},
  author={Takashi Matsushita and Yasuhito Hamaguchi and Minoru Hasegawa and Kazuhiko Takehara and M Fujimoto},
  journal={Rheumatology},
  year={2016},
  volume={55 2},
  pages={263-7}
}
OBJECTIVE B cell abnormalities characterized by autoantibody production and polyclonal B cell activation play an important role in the pathogenesis of SSc. IL-10 producing regulatory B (Breg) cells also play an important role in the negative immune response. We identified a human Breg cell subset that was predominantly found within the CD24(hi)CD27(+) B cell subpopulation. However, the role of Breg cells in SSc remains unknown. The aim of this study was to investigate the clinical association… CONTINUE READING

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