Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?

@article{Beishuizen2002DecreasedLO,
  title={Decreased levels of dehydroepiandrosterone sulphate in severe critical illness: a sign of exhausted adrenal reserve?},
  author={Albertus B Beishuizen and Lambertus G. Thijs and Istv{\'a}n Vermes},
  journal={Critical Care},
  year={2002},
  volume={6},
  pages={434 - 438}
}
INTRODUCTION Dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are pleiotropic adrenal hormones with immunostimulating and antiglucocorticoid effects. The present study was conducted to evaluate the time course of DHEAS levels in critically ill patients and to study their association with the hypothalamic-pituitary-adrenal axis. MATERIALS AND METHOD This was a prospective observational clinical and laboratory study, including 30 patients with septic shock, eight patients with multiple… CONTINUE READING

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