Decreased intracellular GABA levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of KCC2 and GABA(A) receptor-mediated inhibition.

@article{Janssen2012DecreasedIG,
  title={Decreased intracellular GABA levels contribute to spinal cord stimulation-induced analgesia in rats suffering from painful peripheral neuropathy: the role of KCC2 and GABA(A) receptor-mediated inhibition.},
  author={Sofie P M Janssen and St{\'e}phane G{\'e}rard and Marjolein E A Raijmakers and Michiel Truin and Maarten van Kleef and Elbert A. J. Joosten},
  journal={Neurochemistry international},
  year={2012},
  volume={60 1},
  pages={21-30}
}
Elevated spinal extracellular γ-aminobutyric acid (GABA) levels have been described during spinal cord stimulation (SCS)-induced analgesia in experimental chronic peripheral neuropathy. Interestingly, these increased GABA levels strongly exceeded the time frame of SCS-induced analgesia. In line with the former, pharmacologically-enhanced extracellular GABA levels by GABA(B) receptor agonists in combination with SCS in non-responders to SCS solely could convert these non-responders into… CONTINUE READING
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