Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C.

@article{Murakami2004DecreasedIP,
  title={Decreased interferon-alpha production and impaired T helper 1 polarization by dendritic cells from patients with chronic hepatitis C.},
  author={Hideyuki Murakami and Sk Md Fazle Akbar and Hidetaka Matsui and Norio Horiike and Morikazu Onji},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={137 3},
  pages={559-65}
}
Patients with chronic hepatitis C (CHC) are unable to prime and maintain vigorous T cell responses that are initiated during the acute phase of hepatitis C virus (HCV) infection. As dendritic cells (DCs) induce and regulate both innate and adaptive immune responses, the aim of this study was to analyse two critical functions of DCs: firstly, production of interferon (IFN)-alpha and, secondly, polarization of T helper 1 lymphocytes. The frequencies of plasmacytoid DC (PDC) and myeloid DC (MDC… CONTINUE READING