Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice

@article{SackmannSala2011DecreasedIS,
  title={Decreased insulin sensitivity and increased oxidative damage in wasting adipose tissue depots of wild-type mice},
  author={Lucila Sackmann-Sala and Darlene E. Berryman and Ellen R. Lubbers and Clare B. Vesel and Katie M. Troike and Edward O. List and Rachel D. Munn and Yuji Ikeno and John J. Kopchick},
  journal={AGE},
  year={2011},
  volume={34},
  pages={1225-1237}
}
Unintentional weight loss (wasting) in the elderly is a major health concern as it leads to increased mortality. Several studies have focused on muscle loss, but little is known about the mechanisms giving rise to loss of fat mass at old ages. To investigate potential mechanisms, white adipose tissue (WAT) characteristics and proteomic profiles were compared between adult (10–12-month-old) and aged (22–24-month-old) wild-type mice. Four individual WAT depots were analyzed to account for… CONTINUE READING
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Heterogeneity among white adipose tissue depots in male C 57 BL / 6 J mice

  • L Sackmann-Sala, DE Berryman, RD Munn, ER Lubbers, JJ Kopchick
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