Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.

@article{Jackson2000DecreasedIR,
  title={Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families.},
  author={Sue Jackson and Stephanie M Bagstaff and Stephen Lynn and Stephen J. Yeaman and Douglass Matthew Turnbull and Mark J Walker},
  journal={Diabetes},
  year={2000},
  volume={49 7},
  pages={1169-77}
}
To investigate the contribution of inherited biochemical defects to the peripheral insulin resistance of type 2 diabetes, we studied cultured skeletal muscle from 10 insulin-resistant nondiabetic first-degree relatives of type 2 diabetic families and 6 control subjects. Insulin stimulation of glucose uptake and glycogen synthesis was maximal in myoblasts. Insulin-stimulated glucose uptake (fold-stimulation over basal uptake) was decreased in relative compared with control myoblasts at 0.001… CONTINUE READING
30 Citations
62 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 62 references

Similar Papers

Loading similar papers…