Decreased insulin responsiveness in fat cells rendered protein kinase C-deficient by a treatment with a phorbol ester.

@article{Cherqui1987DecreasedIR,
  title={Decreased insulin responsiveness in fat cells rendered protein kinase C-deficient by a treatment with a phorbol ester.},
  author={Gise le Cherqui and M. Caron and Denise Wicek and Olivier Lascols and Jacqueline Capeau and Jacques Picard},
  journal={Endocrinology},
  year={1987},
  volume={120 5},
  pages={
          2192-4
        }
}
Insulin stimulation of 2-deoxyglucose transport and lipogenesis from glucose was examined in fat cells in which protein kinase C had been down-modulated by a 3 h pretreatment with 5 X 10(-7) M 4 beta-phorbol 12 beta-myristate, 13 alpha-acetate (PMA). As compared to control fat cells, the down-modulated cells exhibited a 55-65% decrease in insulin responsiveness with no change in either the hormone sensitivity or the insulin receptor affinity. The present study shows that fat cells made protein… CONTINUE READING
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