Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia.

@article{Wang2008DecreasedIR,
  title={Decreased inflammatory response in Toll-like receptor 2 knockout mice is associated with exacerbated Pneumocystis pneumonia.},
  author={Shao-Hung Wang and Chen Xing Zhang and Mark E. Lasbury and C. L. Liao and Pamela J. Durant and Dennis Tschang and Chao-Hung Lee},
  journal={Microbes and infection},
  year={2008},
  volume={10 4},
  pages={
          334-41
        }
}
Pneumocystis pneumonia (PcP) is marked by substantial inflammatory damage to the lung. We have found that Toll-like receptor 2 (TLR2) mediates macrophage inflammatory responses to Pneumocystis and hypothesized that TLR2 deficiency would lead to less severe inflammation and milder lung injury during PcP. Histopathology examination showed that TLR2-/- mice with PcP indeed exhibited milder pulmonary inflammation. TLR2-/- mouse lungs contained less TNF-alpha and displayed lower levels of NF-kappaB… CONTINUE READING
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Toll like receptors in diseases of the lung.

  • International immunopharmacology
  • 2011
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