Decreased inducible expression of CD80 and CD86 in human monocytes after ultraviolet-B irradiation: its involvement in inactivation of allogenecity.

@article{Fujihara1996DecreasedIE,
  title={Decreased inducible expression of CD80 and CD86 in human monocytes after ultraviolet-B irradiation: its involvement in inactivation of allogenecity.},
  author={Mitsuhiro Fujihara and Tsuneo A. Takahashi and Miyuki Azuma and Chikayo Ogiso and Takami L. Maekawa and H. Yagita and Ko Okumura and Sadayoshi Sekiguchi},
  journal={Blood},
  year={1996},
  volume={87 6},
  pages={2386-93}
}
Ultraviolet-B (UV-B) irradiation of antigen presenting cells (APCs) modifies their allogenecity, resulting in inhibition of the proliferative response of T cells in mixed lymphocyte reaction (MLR). Costimulation by the CD28 ligand CD80 (B7/B7-1) and CD86 (B70/B7-2) plays an important role during T-cell proliferation by augmenting synthesis of interleukin-2 (IL-2) and other cytokines. In this study, we demonstrated induced expression of both CD80 and CD86 during allogeneic MLR, though human… CONTINUE READING

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The mechanism of leukocyte inactivation by ultraviolet - B irradiation : Changes of leukocyte morphology

J Akasaka, TA Takahashi, T Maekawa, S Fujikawa, S Sekiguchi
Jpn J Transfus Med • 1994

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